Dovetail Genomics Unveils Revolutionary TopoLink Assay for 3D Genomics

Dovetail Genomics, a leading provider of innovative genomics solutions and a subsidiary of Cantata Bio, is thrilled to announce the release of the highly anticipated Dovetail® TopoLink™ Assay. This cutting-edge assay represents a significant advancement in the field of 3D genomics, offering researchers an unparalleled solution for studying chromatin architecture.

3D genomics studies the 3D structure of chromosomes, known as chromatin topology. This refers to how DNA and its associated proteins are organized in a cell's nucleus. The organization of chromatin topology is important for various cellular processes. When it is disrupted, it can contribute to diseases like cancer and developmental disorders.

The Dovetail® TopoLink™ Assay complements Dovetail’s existing flagship product, the Dovetail® Micro-C Assay, which provides the highest resolution view of the 3D genome. With the introduction of the TopoLink™ Assay, researchers can now benefit from a faster, more cost-effective, and higher-quality method for generating data.

Key features and benefits of the Dovetail® TopoLink™ Assay include:

  1. Reduced Data Generation Time: The new assay significantly cuts down the time required to generate data, allowing researchers to obtain valuable insights in a fraction of the time compared to traditional methods.

  2. Improved Data Quality: By leveraging state-of-the-art technology, the TopoLink™ Assay enhances overall data quality, enabling the detection of more genomic features with increased accuracy and sensitivity.

  3. Cost-Efficiency: Researchers can now generate high-quality data at a significantly reduced cost per datapoint, making it an ideal solution for larger studies and core labs seeking to maximize their resources.

“We are very excited to be releasing this transformative assay to the research community. While powerful, Traditional Hi-C, the preferred approach to studying the 3D genome, is cumbersome and slow, taking 2-3 days just to get samples onto the DNA sequencer. Now with the Dovetail® TopoLink™ Assay, researchers can get their samples onto the sequencer in a single day, greatly accelerating data generation. In addition, the improved data quality offered by the assay increases the discovery potential, even at lower sequencing depths, further adding to the assays value.” Mathew Easterday, Ph.D. J.D. CEO Cantata Bio.   

To learn more about the Dovetail® TopoLink™ Assay and its applications, researchers and interested parties are encouraged to download the comprehensive eBook available at

About Dovetail Genomics

Dovetail Genomics, a subsidiary of Cantata Bio, is a leading provider of genomics solutions focused on understanding the complex organization of the genome. By delivering cutting-edge technologies and innovative approaches, Dovetail Genomics empowers researchers to unravel the intricacies of chromatin architecture and unlock new insights into gene regulation.